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KMID : 0895820200300010063
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Journal of Oriental Rehabilitation Medicine
2020 Volume.30 No. 1 p.63 ~ p.78
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Epigenetic Modification in Chronic Pain: A Literature Review
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Song Eun-Mo
Cho Hong-Seok
Kim Koh-Woon
Cho Jae-Heung
Park Hi-Joon
Song Mi-Yeon
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Abstract
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Objectives To review the epigenetic modifications involved in chronic pain and to improve individualized intervention for the chronic pain.
Methods Focused literature review.
Results Significant laboratory and clinical data support that epigenetic modifications have a potential role for development of chronic pain.
Conclusions Epigenetic approach may identify mechanisms critical to the development of chronic pain after injury, and may provide new pathways and target mechanisms for future treatment and individualized medicine.
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KEYWORD
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Chronic pain, Epigenomics, Histones, MicroRNAs, DNA methylation
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